منابع مشابه
Pluripotency without Proliferation
Mouse embryonic stem cells (mESCs) are capable of unlimited proliferation without losing pluripotency. Scognamiglio et al. now reveal that Myc depletion shifts mESCs into a dormant state reminiscent of embryonic diapause in which pluripotency remains fully preserved, thus decoupling pluripotency from proliferative programs.
متن کاملMaintenance of pluripotency in mouse ES cells without Trp53
Tumor suppressor Trp53 works as a guardian of the genome in somatic cells. In mouse embryonic stem (ES) cells, it was reported that Trp53 represses pluripotency-associated transcription factor Nanog to induce differentiation. However, since Trp53-null mice develop to term, Trp53 is dispensable for both the maintenance and differentiation of the pluripotent stem cell population in vivo, suggesti...
متن کاملNeural Stem Cells Achieve and Maintain Pluripotency without Feeder Cells
BACKGROUND Differentiated cells can be reprogrammed into pluripotency by transduction of four defined transcription factors. Induced pluripotent stem cells (iPS cells) are expected to be useful for regenerative medicine as well as basic research. Recently, the report showed that mouse embryonic fibroblasts (MEF) cells are not essential for reprogramming. However, in using fibroblasts as donor c...
متن کاملInduction of Pluripotency in Adult Equine Fibroblasts without c-MYC
Despite tremendous efforts on isolation of pluripotent equine embryonic stem (ES) cells, to date there are few reports about successful isolation of ESCs and no report of in vivo differentiation of this important companion species. We report the induction of pluripotency in adult equine fibroblasts via retroviral transduction with three transcription factors using OCT4, SOX2, and KLF4 in the ab...
متن کاملStabilization of Max-Min Fair Networks without Per-flow State
Let a flow be a sequence of packets sent from a source computer to a destination computer. Routers at the core of the Internet do not maintain any information about the flows that traverse them. This has allowed for great speeds at the routers, at the expense of providing only best-effort service. In this paper, we consider the problem of fairly allocating bandwidth to each flow. We assume some...
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ژورنال
عنوان ژورنال: Cell Stem Cell
سال: 2011
ISSN: 1934-5909
DOI: 10.1016/j.stem.2011.06.010